Looking for a day/weekend trip to de-stress, but don't know where to go.

When I lived in AZ, I'd go to San Diego for a weekend and sit at the beach. Or to Tucson to visit friends. I don't know anyone within at least 1000 miles and have had a hellish time for the last 3 months. I need to just get a change of scenery and de-stress. Where can I go that's within a day's drive? What is there to do in this cold (to me) weather?