A movie where 2 people are connected through the decades

I just watched handcock again and I loved the theme surrounding will smith and Charlize theron's character That they are both immortal and always find a way back to each other.

I was wondering there's any similar films out there. Something to do with 2 people being connected. Bonus points if it involves immortality, super powers, evolved people etc... with themes of fate, love and destiny.

Many thanks