Notable towns or cities that feel like outliers?

What are some examples of towns or cities that geographically feel disconnected from the rest of a state?

I'll use Arizona as an example.

Now, with Arizona, your first instinct is to think of Flagstaff. Because it is 7,000 feet high and is surrounded by pine forests, it definitely doesn't fit the mold of cactus and desert that you think of with Arizona.

But I'm going to argue against Flagstaff. Flagstaff is well known in AZ, sits along an (almost) transcontinental intestate, is near the Grand Canyon, and houses one of the state's principal public universities. My vote is actually Yuma. Yuma is a pretty decent sized small city with 100,000 people. Bigger than Flagstaff. And it's on the Colorado River. But for some reason, there's just this unshakable feeling that it's disconnected in some way. I've lived in AZ for years and it never comes up in conversation unless it's in reference to getting gas on the way to San Diego or winter lettuce. If I'm naming cities in AZ I always forget about it. It's a geographic outlier in a map.

Starting in Tucson, there's a natural progression of population that goes up to Phoenix and loosely continues through Prescott, Sedona and finally Flagstaff. But Yuma is in the middle of conplete nowhere and just kind of pops up out of the blue. It's the hottest city in the US but Phoenix gets all the accolades for heat.