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Madison Howard

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Accomplished-Ice9193

2025-02-27 14:13:43

Keto is doing something

Find-PSSD-Cure

2025-02-20 22:07:18

Melatonin - HUGE Improvements (My Experience)

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Ketogenic diets are basically a high protein/low carb diet. Tryptophan benefits from carbohydrates because they cause insulin release, which lowers the amount of competing amino acids that get transported across the BBB via LAT1. With less competition, you have more tryptophan being transported via LAT1 across the BBB to the DRN (Dorsal Raphe Nucleus), where they will go through two steps (TPH2 changing it to 5HTP then AADC changing it to 5HT or "serotonin.") and be stored in vesicles by VMAT2.

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Hi why do you take melatonin the next day in the morning?

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Hello! To try to keep consistent levels in my body throughout the day so that if there really is inhibition of 5HT release going on, it's happening for longer.

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There is literally "anti-SRIs" available OTC called cyproheptdaine, it is also antidot for serotonin toxicity (syndrome). It helps some cases of PSSD.

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I am somewhat familiar with Cyproheptadine and have taken it several times in the past. It's an antagonist of serotonin receptors, primarily 5HT2A/2C. There is weaker antagonist activity at the 5HT1A autoreceptor, which is where we primarily want upregulation. Also, it does not enhance or upregulate SERT, so in my opinion, I would not call it the "anti-SSRI."

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